Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4)-PNP pnp 98 SMILES: CC1(C)\C(=C/C=C/C2=[N+](CCCCCC(=O)NCCN3C(=O)C=CC3=O)C3=CC=C(C=C3C2(C)C)S(O)(=O)=O)N(CCCS([O-])(=O)=O)C2=CC=C(C=C12)S(O)(=O)=O Purity (HPLC):

98 SMILES: CC1(C)\C(=C/C=C/C2=[N+](CCCCCC(=O)NCCN3C(=O)C=CC3=O)C3=CC=C(C=C3C2(C)C)S(O)(=O)=O)N(CCCS([O-])(=O)=O)C2=CC=C(C=C12)S(O)(=O)=O Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

The water soluble 5(6)-TAMRA PEG3 alkyne has a long PEG3 spacer that separates the dye tetramethylrhodamine (commonly known as TMR or TAMRA) from the terminal acetylene group

such as the copper-catalyzed azide-alkyne cycloaddition (CuAAC) and the strain-promoted alkyne-azide cycloaddition (SPAAC)

Product Name Phthalimidinoglutarimide-propargyl-PEG3-OH Synonyms Phthalimidinoglutarimide-4'-propargyl-PEG3-OH CAS Number n/a Related CAS Molecular Formula C22H26N2O7 Molecular Weight 430

58 SMILES [2H]C([2H])([2H])OC1=CN=C(Cl)N=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4)-PNP pnp 98 SMILES: CC1(C)\C(=C/C=C/C2=[N+](CCCCCC(=O)NCCN3C(=O)C=CC3=O)C3=CC=C(C=C3C2(C)C)S(O)(=O)=O)N(CCCS([O-])(=O)=O)C2=CC=C(C=C12)S(O)(=O)=O Purity (HPLC):SOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG6 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating